Cancer germline genomics: from biological insights to genomic predictions

演讲人: Edwin Wang University of Calgary
时间: 2018-11-20 15:00-2018-11-20 16:00
地点:FIT 1-222

Advances in genome sequencing technology allow to generating a large amount of genomic data for tumors and paired normal samples. Traditionally, somatic mutations and other genomic alternations in tumor genomes have been widely explored and studied. Thus far, only limited research groups have worked on germline genomics of cancer. Here I will present several studies in cancer germline genomics which have been done in the past few years. The first part includes new insights into cancer biology, highlighting the importance of the germline genomes for tumorigenesis, metastasis, and guidance in treatment. The second part includes conceptual frameworks, and new algorithms to use germline genomic data to predict clinical outcomes and somatic mutations for early cancer detection.         




Edwin has a undergraduate training in Computer Science and a PhD training in Molecular Genetics (UBC - University of British Columbia, 2002). After one-year postdoc training at FlyBase, a genome database of fly, he moved to NRC as a PI. In 2016, he became an AISH Chair Professor at University of Calgary.  His pioneering work of cancer network motifs has been featured in the college textbook, GENETICS (2014/2017) written by a Nobel Laureate, Dr. Hartwell and the father of systems biology, Dr. Hood.