清华大学交叉信息研究院

赵诞
职务: 助理研究员
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研究方向

结构生物学,表观遗传学,生物化学,计算与实验相结合的药物筛选

 

教育背景:

2018/10 – 至今               助理研究员     清华大学    交叉信息研究院

2016/10 – 2018/10         博士后             清华大学    医学院

2015/04 – 2015/09         访问学者­­         耶鲁大学    遗传系、干细胞中心

2011/09 – 2016/07          博士               北京大学    生命科学学院

2007/09 –2011/07           学士               兰州大学    生命科学学院

 

奖励及项目支持:

2019    国家自然科学基金-青年科学基金

2016    全国博士后创新人才扶持计划

2015    北京大学研究生专项奖学金

2014   北京大学社会工作奖

2013   北京大学五四奖学金

2010    国家励志奖学金

2009    国家奖学金

 

论文发表:

1. Peiyuan Feng#, An Xiao#, Meng Fang, Fangping Wan, Shuya Li, Peng Lang, Dan Zhao*, and Jianyang Zeng*. A novel machine learning based framework for modeling transcription elongation. Proc Natl Acad Sci USA, 2021

2. Dan Zhao#, Weifan Xu#, Xiaofan Zhang#, Xiaoting Wang, Enming Yuan, Yuanpeng Xiong, Shenyang Wu, Shuya Li, Nian Wu, Tingzhong Tian, Xiaolong Feng, Hantao Shu, Peng Lang, Xiaokun Shen, Haitao Li, Pilong Li,* and Jianyang Zeng*. Understanding the phase separation characteristics of nucleocapsid protein provides a new therapeutic opportunity against SARS-CoV-2. Protein & Cell, 2021

3. Yuanpeng Xiong#, Xuan He#, Dan Zhao, Tingzhong Tian, Lixiang Hong, Tao Jiang*, and Jianyang Zeng*. Modelling Multi-species RNA Modification through Multi-task Curriculum Learning. Nucleic Acids Research, 2021

4. Yiyue Ge#, Tingzhong Tian#, Suling Huang#, Fangping Wan#, Jingxin Li#, Shuya Li, Xiaoting Wang, Hui Yang, Lixiang Hong, Nian Wu, Enming Yuan, Yunan Luo, Lili Cheng, Chengliang Hu, Yipin Lei, Hantao Shu, Xiaolong Feng, Ziyuan Jiang, Yunfu Wu, Ying Chi, Xiling Guo, Lunbiao Cui, Liang Xiao, Zeng Li, Chunhao Yang, Zehong Miao, Ligong Chen, Haitao Li, Hainian Zeng, Dan Zhao*, Fengcai Zhu*, Xiaokun Shen*, and Jianyang Zeng*. An integrative drug repositioning framework discovered a potential therapeutic agent targeting COVID-19. Signal Transduction and Targeted Therapy, 2021

5. Lixiang Hong, Jinjian Lin, Shuya Li, Fangping Wan, Hui Yang, Tao Jiang, Dan Zhao*, and Jianyang Zeng*. A novel machine learning framework for automated biomedical relation extraction from large-scale literature repositories. Nature Machine Intelligence, 2020.

6. Shuya Li#, Fangping Wan#, Hantao Shu, Tao Jiang, Dan Zhao*, Jianyang Zeng*. MONN: A Multi-objective Neural Network for Predicting Compound-Protein Interactions and Affinities. Cell Systems, 2020

7. Fangping Wan#, Shuya Li#, Tingzhong Tian, Yipin Lei, Dan Zhao*, Jianyang Zeng*. EXP2SL: a Machine Learning Framework for Cell-Line Specific Synthetic Lethality Prediction. Frontiers in Pharmacology, 2020

8. Chih-Chao Hsu#, Dan Zhao#, Jiejun Shi#, Danni Peng, Haipeng Guan, Yuanyuan Li, Yaling Huang, Hong Wen, Wei Li*, Haitao Li* and Xiaobing Shi*. Gas41 links histone acetylation to H2A.Z deposition and maintenance of embryonic stem cell identity. Cell Discovery, 2018, 4:28

9. Chih-Chao Hsu*, Jiejun Shi*, Chao Yuan*, Dan Zhao*, Shiming Jiang, Jie Lyu, Xiaolu Wang, Haitao Li, Hong Wen, Wei Li, and Xiaobing Shi. Recognition of histone acetylation by the GAS41 YEATS domain promotes H2A.Z deposition in non-small cell lung cancer. Genes Dev, 2018, 32(1):58-69

10. Wenyi Mi#, Haipeng Guan#, Jie Lyu#, Dan Zhao#, Yuanxin Xi, Shiming Jiang, Forest H. Andrews, Xiaolu Wang, Mihai Gagea, Hong Wen, Laszlo Tora, Sharon Y.R. Dent, Tatiana G. Kutateladze, Wei Li*, Haitao Li* and Xiaobing Shi*. YEATS2 links histone acetylation to tumorigenesis of non-small cell lung cancer. Nature Communications, 2017, 8(1):1088

11. Dan Zhao, Yuanyuan Li, Xiaozhe Xiong, Zhonglei Chen, Haitao Li. YEATS Domain-A Histone Acylation Reader in Health and Disease. J Mol Biol, 2017, 429(13): 1994-2002.

12. Zhuang Li, Dan Zhao, Bin Xiang, and Haitao Li. Structural and biochemical characterization of DAXX-ATRX interaction. Protein Cell, 2017, 8(10):762-766

13. Yuanyuan Li, Dan Zhao, Zhonglei Chen, and Haitao Li. YEATS domain: Linking Histone Crotonylation to Gene Regulation. Transcription, 2017, 8(1):9-14

14. Yuanyuan Li, Benjamin R. Sabari, Tatyana Panchenko, Hong Wen, Dan Zhao, Haipeng Guan, Liling Wan, He Huang, Zhanyun Tang, Yingming Zhao, Robert G. Roeder, Xiaobing Shi, C. David Allis, and Haitao Li. Molecular Coupling of Histone Crotonylation and Active Transcription by AF9 YEATS Domain. Molecular Cell, 2016, 62(2):181-93

15. Dan Zhao, Haipeng Guan, Shuai Zhao, Wenyi Mi, Hong Wen, Tiemei Li, Yuanyuan Li, Yingming Zhao, C. David Allis, Or Gozani, Xiaobing Shi and Haitao Li. YEATS2 is a selective histone crotonylation reader. Cell Research, 2016, 26(5):629-632

16. Dan Zhao, Xiaojie Zhang, Haipeng Guan, Xiaozhe Xiong, Xiaomeng Shi, Haiteng Deng, Haitao Li. The BAH domain of BAHD1 is a histone H3K27me3 reader. Protein & Cell, 2016, 7(3):222-226

17. Xiaojie Zhang, Dan Zhao, Xiaozhe Xiong, Zhimin He, and Haitao Li. Multifaceted Histone H3 Methylation and Phosphorylation Readout by the Plant Homeodomain Finger of Human Nuclear Antigen Sp100C. J Biol Chem, 2016, 291(24):12786-98

18. Kyung-Min Noha#, Ian Mazeb#, Dan Zhao#, Bin Xiang, Wendy Wenderski, Peter W. Lewis, Li Shen, Haitao Li* and C. David Allis*. ATRX tolerates activity-dependent histone H3 methyl/phos switching to maintain repetitive element silencing in neurons. Proc Natl Acad Sci USA, 2015,112(22):6820-6827